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The hospitality industry in Lagos, Nigeria, is plagued by occupational health hazards, largely due to inadequate risk factor management. This study investigates the impact of risk factor management on the occupational health of staff in the hospitality industry. The main objective of this study is to examine the impact of high-risk activities on the health and safety of staff in the Lagos hospitality industry. A cross-sectional research design employing a quantitative approach was used. The target population comprised 1,589 staff from 20 top hotels in Lagos, with a sample size of 320. The study used the combination of purposive, proportional and random sampling techniques respectively. Correlation and hierarchical regression analysis revealed significant relationships between variables of the study. The study revealed that risk management and occupational risk are significant predictors of staff health and safety. Specifically, the results indicate that work-related injuries and illnesses, which are common consequences of high-risk activities, significantly predict the need for mitigation strategies such as training and safety protocols. Based on the findings of this study, the researcher recommended that Hospitality businesses in Lagos should prioritize the safety and well-being of their employees by implementing effective mitigation strategies, such as training and safety protocols; Business experts and practitioners in Lagos should adopt a more proactive approach to managing risk by identifying potential hazards and taking steps to mitigate them; and the Lagos State Government should develop policies and programs aimed at improving the health and safety of employees in the hospitality industry.